It is huffing, so if huffing is unhealthy or dangerous, then poppers can be. I've never huffed/inhaled anything before so I don't know personally, other than what I know is safe, harmful, and dangerous.
I did do poppers against my will though. I was about to get fucked by my transwoman escort (first time with her 3 years ago) and while on my back ready for her to do me good, she pushed something in my face I couldn't see what it was and said "sniff this it'll help you relax" and I smelled, not sniffed, something I did not like, chemical aroma, but I think I breathed in more than I wanted. Prior to that I had an amazing erection for about 30 minutes of head and hand play. Immediately after smelling that thing, I lost my boner and never got it back. I had taken cialis several hours earlier, and I think the combo of cialis and popper ruined my boner. I felt hot everywhere, kind of elevated bloodflow in my whole body, I had a hard time "catching" my breath like I was tired out but hadn't done much, wiped out feeling, and pretty done. I never got hard again and never got to cum, although two rounds of her fucking me gave me several strong Pspot Os. I didn't get final release.
So I've read that ED meds and poppers don't mix, but people mix them. For me I don't think they mixed. It was uncool she did that and the next time I saw her I told her I don't get down like that! I had no performance issues second go around
